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Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG
《医学前沿(英文)》 2009年 第3卷 第2期 页码 164-170 doi: 10.1007/s11684-009-0038-1
关键词: epithelial-mesenchymal transition vascular endothelial cell growth factor matrix metalloproteinase-9 cyclooxygenase-2 higher microvascular density breast cancer
Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 72-76 doi: 10.1007/s11684-014-0347-x
Periodontitis is an inflammatory disease of the periodontium. Any imbalance between the matrix metalloproteinases (MMPs) secreted by neutrophils and tissue inhibitors initiates the destruction of collagen in gum tissue, leading to chronic periodontitis. This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitis to establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis. The study involved 40 subjects visiting the periodontic OPD of Dr. Ziauddin Ahmad Dental College and Hospital, located in Aligarh, U.P., India, from 2011 to 2012. The subjects were divided into two groups: group I consisted of 20 periodontally healthy subjects (controls) while group II consisted of 20 patients with chronic periodontitis. Chronic periodontitis was assessed on the basis of several periodontal parameters, including pocket probing depth (PPD), clinical attachment level (CAL), gingival index (GI), and plaque index (PI). Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISA using Quantikine human total MMP-8 immunoassay kits. Data were analyzed using STATISTICA (Windows version 6) software. Salivary MMP-8 levels of groups I and II were 190.91±143.89 ng/ml and 348.26±202.1 ng/ml, respectively. The MMP-8 levels and periodontal status (PPD, CAL, GI, and PI) of groups I and II showed positive and significant correlations (for PPD, r = 0.63, P<0.001; for CAL, r = 0.54, P<0.001; for GI, r = 0.49, P<0.001; and for PI, r = 0.63, P<0.001). The results of this study demonstrate elevated concentrations of MMP-8 in individuals with chronic periodontitis.
关键词: matrix metalloproteinase-8 chronic periodontitis pocket probing depth clinical attachment level gingival index plaque index
Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal
Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang
《医学前沿(英文)》 2020年 第14卷 第1期 页码 91-100 doi: 10.1007/s11684-019-0696-6
关键词: HOXB9 AcK27-HOXB9 PDAC
Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 415-420 doi: 10.1007/s11684-009-0072-z
关键词: tissue inhibitor of metalloproteinase-3 intervertebral disc rabbit gene therapy
662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
QU Yanchun, YANG Ze, SUN Liang, JI Linong
《医学前沿(英文)》 2008年 第2卷 第3期 页码 283-285 doi: 10.1007/s11684-008-0053-7
关键词: D-HPLC mutation development autoimmune PCR-RFLP candidate
The 9th China Engineering Management Forum Guangzhou Consensus
《工程管理前沿(英文)》 2015年 第2卷 第2期 页码 105-107 doi: 10.15302/J-FEM-2015019
Mobile CRISPR-Cas9 based anti-phage system in E. coli
《化学科学与工程前沿(英文)》 2022年 第16卷 第8期 页码 1281-1289 doi: 10.1007/s11705-022-2141-7
关键词: phage infections anti-phage CRISPR-Cas9 conjugative transfer synthetic biology
REDUCTION OF NON-POINT SOURCE POLLUTION IN THE YONG’AN RIVER BY CONSTRUCTED WETLAND BASED ON 9 YEARS
《农业科学与工程前沿(英文)》 2023年 第10卷 第4期 页码 627-638 doi: 10.15302/J-FASE-2023516
The agricultural and livestock activities surrounding the rivers flowing into the lakes have caused non-point source pollution, leading to excessive amounts of nutrient salts in downstream rivers. Introducing river water into constructed wetlands along river course has proven to be an effective solution for decreasing nitrogen (N) and phosphorus (P) loads. This paper reports 9 years of monitoring the Yong’an River and its surrounding constructed wetlands in the upper reaches of Erhai Lake, located in Yunnan Province, China. This study analyzed the main types of pollutants in the river, and evaluated the removal efficiency of pollutants by the constructed wetlands. The findings indicate that total nitrogen (TN) and nitrate nitrogen (NO3–-N) are the primary pollutants in the Yong’an River, which exhibit variation throughout the year corresponding to the alternating wet and dry seasons. Although constructed wetlands are effective in removing NO3–-N and P, their efficacy in removing ammonium nitrogen (NH4+-N) and organic pollutants is limited. This limitation can be attributed to the lack of timely disposal of aquatic plant residues. This research contributes to the understanding of the potential issues that may arise during the extended use of constructed wetlands and provides solutions to address them.
关键词: inflowing rivers surface-flow constructed wetland nutrients long-term monitoring
Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain
Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI
《医学前沿(英文)》 2009年 第3卷 第2期 页码 141-147 doi: 10.1007/s11684-009-0041-6
CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 554-562 doi: 10.1007/s11684-017-0543-6
T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advanced refractory B cell malignancy. However, many challenges remain in extending its application toward the treatment of solid tumors. The immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-T efficacy. One negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3). We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using CRISPR-Cas9 mediated gene editing and found that the viability and immune phenotype were not dramatically changed during in vitro culture. LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity in cell culture and in murine xenograft model, which is comparable to standard CAR-T cells. Our study demonstrates an efficient approach to silence immune checkpoint in CAR-T cells via gene editing.
关键词: CAR-T CRISPR-Cas9 LAG-3
Compiling of comprehensive data of human infections with novel influenza A (H7N9) virus
null
《医学前沿(英文)》 2013年 第7卷 第3期 页码 275-276 doi: 10.1007/s11684-013-0285-z
Research progress on human infection with avian influenza H7N9
Xiaoxin Wu, Lanlan Xiao, Lanjuan Li
《医学前沿(英文)》 2020年 第14卷 第1期 页码 8-20 doi: 10.1007/s11684-020-0739-z
Decellularized extracellular matrix mediates tissue construction and regeneration
《医学前沿(英文)》 2022年 第16卷 第1期 页码 56-82 doi: 10.1007/s11684-021-0900-3
关键词: decellularized extracellular matrix 3D culture organoids tissue repair
Perspective of mixed matrix membranes for carbon capture
Shinji Kanehashi, Colin A. Scholes
《化学科学与工程前沿(英文)》 2020年 第14卷 第3期 页码 460-469 doi: 10.1007/s11705-019-1881-5
Frequency domain a9ctive vibration control of a flexible plate based on neural networks
Jinxin LIU, Xuefeng CHEN, Zhengjia HE
《机械工程前沿(英文)》 2013年 第8卷 第2期 页码 109-117 doi: 10.1007/s11465-013-0252-z
A neural-network (NN)-based active control system was proposed to reduce the low frequency noise radiation of the simply supported flexible plate. Feedback control system was built, in which neural network controller (NNC) and neural network identifier (NNI) were applied. Multi-frequency control in frequency domain was achieved by simulation through the NN-based control systems. A pre-testing experiment of the control system on a real simply supported plate was conducted. The NN-based control algorithm was shown to perform effectively. These works lay a solid foundation for the active vibration control of mechanical structures.
关键词: active vibration control (AVC) neural network (NN) low frequency noise frequency domain control multi-frequency control
标题 作者 时间 类型 操作
Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9,
Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG
期刊论文
Acetylated HOXB9 at lysine 27 is of differential diagnostic value in patients with pancreatic ductal
Xiaoran Sun, Jiagui Song, Jing Zhang, Jun Zhan, Weigang Fang, Hongquan Zhang
期刊论文
Adenovirus-mediated tissue inhibitor of metalloproteinase-3 gene transfection inhibits rabbit intervertebral
Xudong YU MM, Zengwu SHAO MD, Liming XIONG MD, Weiwei XU MM, Hezhong WANG MM, Huifa XU MM,
期刊论文
662 A/G gene variation in human tumor necrosis factor receptor superfamily, member 9 (TNFRSF9)
QU Yanchun, YANG Ze, SUN Liang, JI Linong
期刊论文
REDUCTION OF NON-POINT SOURCE POLLUTION IN THE YONG’AN RIVER BY CONSTRUCTED WETLAND BASED ON 9 YEARS
期刊论文
Construction of lentiviral vector carrying Rab9 gene and its expression in mouse brain
Youguo HAO, Min ZHANG, Jinzhi XU, Bitao BU, Jiajun WEI
期刊论文
Research progress on human infection with avian influenza H7N9
Xiaoxin Wu, Lanlan Xiao, Lanjuan Li
期刊论文